ABT-263 (Navitoclax)
$8.99
C-1009Targets: BCL-2Synonym: ABT-263; ABT263; ABT 263; NavitoclaxChemical Name/IUPAC:(R)-4-(4-((4′-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide SMILES Code: O=C(NS(=O)(C1=CC=C(N[C@H](CCN2CCOCC2)CSC3=CC=CC=C3)C(S(=O)(C(F)(F)F)=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4Technical DataProduct Name: ABT-263 (Navitoclax)Chemical Formula: C47H55ClF3N5O6S3Moleculer Weight: 974.61CAS#: 923564-51-6Appearance: Solid powderPurity: > 99% by HPLCSolubility: Soluble in DMSOStorage: Room temperature for months, or -20ºC for 3 yearsDescription ABT-263 (Navitoclax) is an orally bioavailable, small-molecule antagonist of a subset of…
- C-1009
- Targets: BCL-2
- Synonym: ABT-263; ABT263; ABT 263; Navitoclax
- Chemical Name/IUPAC:(R)-4-(4-((4′-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide SMILES Code: O=C(NS(=O)(C1=CC=C(N[C@H](CCN2CCOCC2)CSC3=CC=CC=C3)C(S(=O)(C(F)(F)F)=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4
-
Technical Data
- Product Name: ABT-263 (Navitoclax)
- Chemical Formula: C47H55ClF3N5O6S3
- Moleculer Weight: 974.61
- CAS#: 923564-51-6
- Appearance: Solid powder
- Purity: > 99% by HPLC
- Solubility: Soluble in DMSO
- Storage: Room temperature for months, or -20ºC for 3 years
-
Description
ABT-263 (Navitoclax) is an orally bioavailable, small-molecule antagonist of a subset of BCl-2 (B-cell leukemia 2) family of proteins with potential antineoplastic activity. ABT-263 selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.
Be the first to review “ABT-263 (Navitoclax)”
Related products
Reviews
There are no reviews yet.